The Europa League is set to kick off on Wednesday with both teams set to play their home matches at their respective stadiums.
It has been a busy season for clubs from all over Europe, with Barcelona and Real Madrid already enjoying Champions League football and Real being the surprise package of the season after finishing as runners-up in the competition.
However, in the eyes of many, it could prove to be the toughest of the competitions to watch, as the league’s governing body has revealed a number of players who could be on the move during the competition’s first half.
Here are 10 of the most likely to make an appearance.
Barcelona have already won their Champions League, and will surely be looking to add to their win over Chelsea in the previous round.
Real Madrid, who finished as runners up in the Europa League, will have a tough task of making the most of their Champions Leagues opening round, as they will be facing a host of teams who finished top of their domestic league.
In addition to Lionel Messi, Cristiano Ronaldo and Zlatan Ibrahimovic, the Spanish giants also have several players who are expected to be available for selection in the first half of the campaign.
Alvaro Morata is set for a busy few weeks, as he is expected to return to the Catalan capital for the first time since his return from the World Cup.
The defender will be hoping to continue his success in Spain’s top flight, as Real have only lost one of their opening two games of the competition, as Morata has already bagged four goals.
Marcelo could be the man to lead the line in the second half of this season’s Europa League as Real face Liverpool in the Champions League final, as both teams are already favourites to progress.
Tiago Silva will be one of the main men for Real Madrid in the final as they face Arsenal, with the midfielder also having a lot of experience at the top level.
Lionel Messi is also expected to feature, as his performances in the past few weeks have been very good for the Spanish superstar, as well as the Spanish national team.
Zlatan is expected play his part as well, with his performances so far this season have been fantastic, with Real scoring two goals and conceding just one in the group stages.
Javier Hernandez could also feature, with Juventus looking to end their group stage drought and advance further.
Daley Blind will be looking for another good showing as Manchester United face Manchester City in the quarter-finals, with both sides already favourites for a place in the last 16.
Matic has already shown signs of improvement this season, with Mourinho’s side conceding only one goal in the four games he played.
Antonio Valencia has not featured for either club this season and will be without another striker in the knockout stages, with Borussia Dortmund also looking to reach the last four.
Lucas Moura is another man who could feature in the opening stages, as Valencia has struggled in the European competitions so far, and with Real Madrid having only lost once in the competitions so-far, the defender could be an option for both sides.
The draw for the group stage of the Europa league is set, and both sides will be expected to start their respective games at 9.00pm local time (20:00 GMT), with the draw due to take place at 8.00am on Wednesday, March 10.
You can follow the match from the BBC Sport app, or on the BBC World Service.
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